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5 minutes

Designer Drugs: The Dangerous Side Effects and Addictive Nature of Synthetic Drugs

Medically Reviewed
Last Medically Reviewed on: June 24, 2022
Benzos pills

Updated on

21 Jun, 2022

There are many types of substance abuse. Designer drugs, also known as synthetic drugs, are laboratory-produced substances that have been designed to mimic the pharmacological effects of a legally restricted, prohibited drug. Because designer drugs are illegal, these synthetic drugs are typically produced in “underground” or secret, illegal labs. When creating designer drugs, certain elements and chemical properties from the original drug are altered, producing a different effect on the brain or behavior than what the original drug produces.

Unfortunately, despite the adverse health side-effects of taking such synthetic, laboratory-produced drugs, the Global Drug Survey found that about 20% of people in the U.S. dabbled in synthetic drugs in 2014. That’s one in five people who have used some synthetic drug in 2014 alone.

Furthermore, with the drug crisis on the rise, this number has likely risen since the 2014 survey was conducted. For example, in 2015, there were four times as many reports of negative drug reactions from synthetics in the first few months of the year than in all of 2014 combined. So what exactly are the types of drugs categorized under synthetic drugs, and what are the effects of designer drugs on the body? Additionally, are designer drugs addictive, and how does one get help if they are addicted to designer drugs?

What are Some Types of Designer Drugs?

The U.S. Drug Enforcement Administration, , classifies designer drugs as psychoactive substances (NPS). There are hundreds of different types of designer drugs, but, to simplify things, there are three main categories:

  • Synthetic cathinones: This type of designer drug works as a stimulant by increasing serotonin and dopamine levels in the brain, which activates the brain’s reward center by increasing feelings of happiness and pleasure or attention and motivation.
  • Synthetic cannabinoids: Mimicking the effects of marijuana, synthetic cannabinoids work on the same brain cell receptors as THC. The differences between this synthetic drug and marijuana, however, include the effects produced and the intensity. Synthetic cannabinoids have a much stronger intensity than their marijuana counterpart, and in effect, include much stronger levels of relaxation, elevated mood, altered perception, and even some psychosis symptoms.
  • Synthetic phenethylamine: Categorized as a hallucinogen, this designer drug affects the brain by altering reality through sensory input (sight, sound, taste, and touch). Furthermore, feelings of being “detached” from the body or having “blurred senses,” such as “tasting sights” or “feeling colors,” can occur.

Some of the more common designer drugs are:

  • MDMA (Ecstasy, XTC, or “E”): Classified as an amphetamine, this empathogen causes emotional and social disturbances in the user’s body.
  • Molly: A “purer” form of MDMA, molly is supposedly manufactured without amphetamine. However, because of the lack of manufacturing regulations on synthetic drug production, it is impossible to know if the user is getting pure MDMA.
  • Bath salts: Created in powder form, bath salts were created to mimic methamphetamine’s effects.
  • Synthetic marijuana: Also known as “K2” or “spice,” synthetic marijuana is abused through smoking. The main ingredients in this designer drug have been outlawed because users have been seen to have psychotic reactions, such as paranoia, anxiety, and hallucinations when consuming these ingredients.
  • Gravel: Containing a mixture of bath salts, methamphetamine, and Klonopin (clonozepam), gravel has traces of ammonia nitrate, a flammable chemical in fertilizer. This mixture can cause serious, even fatal damage, to the user.
  • Krokodil: Extremely addictive and deadly, Krokodil contains ingredients that mimic those produced by heroin. In addition, some Krokodil has gasoline and paint-thinner on its list of ingredients.
  • 25i (or “Nbomb” or “Smiles”): This designer drug mimics psychedelic-like substances, such as LSD or “acid.” Taking this drug is extremely dangerous, even fatal in large doses.

This list is not all-inclusive, as hundreds of different types of designer drugs exist. As with any designer drug, the intention is to mimic the effects of illegal drugs. Many of them have similar effects as cocaine or other stimulants. However, others may mimic the effects of benzodiazepines and the clonazepam high.

Cannabinoids, the ones that mimic marijuana, are the most popular and widely abused of all designer drugs. Besides the popularity from the effects and availability of designer drugs, these types of drugs are known for being undetectable with drug testing, making them especially popular among amateur and professional athletes.

What are the Dangerous Side Effects of Designer Drugs?

One of the greatest risks from taking synthetic drugs is that there is no standard for manufacturing, meaning that with no regulation in place, there is no certainty of what the drug may contain. This creates a much higher risk of overdose and possible death. In addition, each drug has unique, adverse effects on the body. For example, MDMA can cause hypertension, cardiac issues, and hyperthermia, each posing possible fatality to the user.

Furthermore, MDMA can cause severe psychological side effects, such as depression, anxiety, and exhaustion. In the case of bath salts, which often contain pesticides and fungicides, users can experience intense spells of terror, anxiety, confusion, hallucinations, and other serious or fatal side effects.

Prolonged use of Krokodil can lead to rotting of the skin and organs and even death. Furthermore, when taking large doses of the synthetic drug 25i, the user can experience severe seizures, paranoia, fear and panic, and, as previously mentioned, possibly death.

Other possible short- or long-term effects of synthetic drugs include:

  • Amnesia
  • Panic attacks
  • Nausea/vomiting
  • Increased or decreased blood pressure
  • Coma
  • Permanent cognitive problems

Are Designer Drugs Addictive?

Someone using designer drugs has the potential to become physically dependent or addicted to the drugs, especially if the user is consistently abusing synthetic drugs for a long time.

Some of the common signs of designer drug addiction include:

  • Isolating or avoiding friends and family
  • Extreme, often intense, mood swings
  • Having memory problems
  • Sleeping too much or too little
  • Going out of one’s way to find more drugs
  • Spending large amounts of money on drugs
  • Having uncharacteristic difficulties at work/school
  • Relationship problems
  • Changes in behavior or appearance

Withdrawal symptoms can occur, as with any drug being abused, especially when usage is stopped abruptly or reduced drastically. The symptoms experienced from quitting synthetic drug use can vary from person to person.

Withdrawal symptoms may include:

  • Difficulty concentrating
  • Severe depression
  • Tremors or muscle spasms
  • Difficulty or inability to fall asleep
  • Loss of appetite

To avoid any potential severe withdrawal symptoms, seek professional medical guidance when considering detoxing off synthetic drugs.

How to Get Help if You’re Addicted to Designer Drugs

If you or someone you know is using designer/synthetic drugs, you can overcome your addiction by seeking a medically-safe detox at a drug rehab center or by seeing a medical doctor. Attending an inpatient/intensive outpatient drug rehab center can help uncover the underlying reasons you abuse drugs in the first place, such as coping with emotional distress or trauma, to prevent future drug use.

Because designer drugs can cause a host of adverse physical and psychological effects to the user, seeking help at the first signs of abuse is essential. Getting the help you need now will set you up for lifetime sobriety, where drug use will no longer define you. Reach out to our team today so you can get the help you need and deserve.


Infinite Recovery has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations for our references. We avoid using tertiary references as our sources. You can learn more about how we source our references by reading our editorial guidelines and medical review policy.

  1. Loria K. One in 10 people around the world gets high off designer drugs. Business Insider. Published May 2, 2015. Accessed June 24, 2022.
  2. Schwarz A. Potent ‘Spice’ Drug Fuels Rise in Visits to Emergency Room. The New York Times.  Published April 24, 2015. Accessed June 24, 2022.
  3. Drug Enforcement Administration. About Synthetic Drugs. Published June 24, 2022. Accessed June 24, 2022.
  4. Science Direct. Phenethylamine – an overview | ScienceDirect Topics. Published June 24, 2022. Accessed June 24, 2022.

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Michael Dadashi

Medical Content Writer

Family owned and operated since 2014, Infinite Recovery was founded by Michael & Ylianna Dadashi to give those struggling with addiction a second chance and help to rebuild their lives. Clean and sober since 2009, Michael is passionate about helping others discover their authentic self and live a life of true freedom and purpose.

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